Journal
HUMAN BRAIN MAPPING
Volume 28, Issue 10, Pages 1023-1032Publisher
WILEY
DOI: 10.1002/hbm.20323
Keywords
temporal lobe; focal epilepsy; default mode; EEG; fMRI; consciousness; resting state
Funding
- Medical Research Council [G9805989, G0301067, G0200216] Funding Source: researchfish
- Medical Research Council [G9805989, G0301067, G0200216] Funding Source: Medline
- Wellcome Trust [067176] Funding Source: Medline
- MRC [G0301067, G9805989] Funding Source: UKRI
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A cerebral network comprising precuneus, medial frontal, and temporoparietal cortices is less active both during goal-directed behavior and states of reduced consciousness than during conscious rest. We tested the hypothesis that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures. At the group level, using electroencephalography-correlated functional magnetic resonance imaging in 19 consecutive patients with focal epilepsy, we found common decreases of resting state activity in 9 patients with temporal lobe epilepsy (TLE) but not in 10 patients with extra-TLE. We infer that the functional consequences of TLE interictal epileptic discharges are different from those in extra-TLE and affect ongoing brain function. Activity increases were detected in the ipsilateral hippocampus in patients with TLE, and in subthalamic, bilateral superior temporal and medial frontal brain regions in patients with extra-TLE, possibly indicating effects of different interictal epileptic discharge propagation.
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