Journal
JOURNAL OF DENTAL RESEARCH
Volume 86, Issue 10, Pages 986-991Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910708601013
Keywords
oral clefts; subphenotype; dental anomalies; agenesis; cleft palate; cleft lip
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Funding
- NIDCR NIH HHS [R21 DE016718-03, R21 DE016718-02, R21-DE016718, R21 DE016718-01, R21 DE016718] Funding Source: Medline
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Individuals with clefts present considerably more dental anomalies than do individuals without clefts. We used dental development to subphenotype clefts with the goal of identifying cleft subgroups that could have specific genetic contributions. We examined 1000 individuals, 500 with clefts and 500 without. We used several clinical features, such as cleft completeness or incompleteness, laterality, and the presence of dental anomalies to assess each individual's cleft status. We performed chi-square and Fisher's exact tests to compare the frequencies of observed anomalies between individuals with and individuals without clefts, and among individuals with different cleft subphenotypes. Agenesis of the lateral incisor on the non-cleft side was the most remarkable observation, and may suggest that such cases could be considered incomplete forms of bilateral clefts of the lip.
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