Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 51, Issue 1, Pages 43-57Publisher
WILEY
DOI: 10.1111/j.1574-695X.2007.00277.x
Keywords
Paracoccidioides brasiliensis; transcription; human plasma
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Paracoccidioides brasiliensis causes infection through host inhalation of airborne propagules of the mycelial phase of the fungus, which reach the lungs, and then disseminate to virtually all parts of the human body. Here we describe the identification of differentially expressed genes in P. brasiliensis yeast cells, by analyzing cDNA populations from the fungus treated with human plasma, mimicking superficial infection sites with inflammation. Our analysis identified transcripts that are differentially represented. The transcripts upregulated in yeast cells during incubation in human plasma were predominantly related to fatty acid degradation, protein synthesis, sensing of osmolarity changes, cell wall remodeling and cell defense. The expression pattern of genes was independently confirmed.
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