Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 81, Issue 4, Pages 842-846Publisher
CELL PRESS
DOI: 10.1086/521201
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Funding
- NIAAA NIH HHS [R01 AA009379, AA009379] Funding Source: Medline
- NIGMS NIH HHS [P01 GM057672, GM057672] Funding Source: Medline
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The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia.
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