Journal
NATURE REVIEWS CANCER
Volume 7, Issue 10, Pages 800-808Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2228
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Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post- trial studies have also revealed proteases with tumour- suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?
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