Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 455, Issue 1, Pages 5-18Publisher
SPRINGER
DOI: 10.1007/s00424-007-0286-3
Keywords
PIP2; PIP5K; actin cytoskeleton; Arf6; endocytosis; phagocytosis
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Funding
- NIGMS NIH HHS [NIH P05GM21681, NIH R01GM06110] Funding Source: Medline
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Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
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