Journal
BRAIN RESEARCH REVIEWS
Volume 55, Issue 2, Pages 343-355Publisher
ELSEVIER
DOI: 10.1016/j.brainresrev.2007.02.006
Keywords
hippocampus; estrogen; glucocorticoid; golgi; electron microscopy
Categories
Funding
- NHLBI NIH HHS [P01 HL018974-280022, P01 HL018974-289002, P01 HL018974, P01 HL018974-299002, P01 HL018974-290022, HL 18974] Funding Source: Medline
- NIDA NIH HHS [R01 DA008259-12, R01 DA008259-11A2, R01 DA008259-12S1, DA 08259, R01 DA008259-14, R01 DA008259-13, R01 DA008259] Funding Source: Medline
- NIMH NIH HHS [R37 MH041256-17, MH 41256, R01 MH042834-12, R01 MH041256, R37 MH041256, R37 MH041256-18] Funding Source: Medline
- NINDS NIH HHS [NS 0007080, R01 NS007080-38, R01 NS007080, R01 NS007080-40, R01 NS007080-39A2, R01 NS007080-37] Funding Source: Medline
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The hippocampus is a malleable brain region that responds to external agents such as hormones and stressors. Investigations that began in our laboratories with the Golgi technique and an appreciation of hippocampal neuroanatomy at the light and electron microscopic levels have led us down a path that has uncovered unexpected structural plasticity in the adult brain along with unanticipated cellular and molecular mechanisms of this plasticity and of hormone mediation of these effects. This chapter reviews the history of discoveries in our two laboratories involving the actions of estradiol and stress hormones on neuronal structure and function and then discusses the insight to hormone-brain interactions that this has engendered.. These discoveries have led us to a new view of brain structural plasticity and the role and mechanism of steroid hormone action involving both genomic and non-genomic pathways. This new view is consistent with the predictions of Cajal in his book The Structure of Ammon's horn, 1892. (C) 2007 Elsevier B.V. All rights reserved.
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