Journal
JOURNAL OF OTOLARYNGOLOGY
Volume 36, Issue 5, Pages 257-263Publisher
B C DECKER INC
DOI: 10.2310/7070.2007.0047
Keywords
adverse drug reaction; azithromycin; ototoxicity; sensorineural hearing loss
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Background: Hearing loss as a possible side effect of azithromycin has been recognized since 1994. Most reports suggesting a link between sensorineural hearing loss (SNHL) and this drug have been in association with prolonged doses for treatment of Mycobacterium lung disease. Mild-moderate, gradual, and reversible SNHL in the speech frequencies has been most often reported. Materials and Methods: We describe irreversible SNHL in a patient in association with low-dose oral azithromycin prescribed for acute otitis media. We summarize the available evidence, including a systematic literature review, in support of a possible causal association between SNHL and low-dose azithromycin therapy. Interpretation/Discussion: Physicians should be aware of the potential for even low-dose, oral azithromycin to cause irreversible SNHL as a serious adverse drug reaction in some patients.
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