Synthesis, characterization, cytotoxicity, antibacterial and antifungal evaluation of some new platinum (IV) and palladium (II) complexes of thiodiamines

Some new platinum (IV) and palladium (II) thiodiamine complexes of type [Pt(L)(2)Cl-2] and [Pd(L)Cl-2], [where, L = (cyclohexyl-N-thio)-1,2ethylenediamine (L-1) and (cyclohexyl-N-thio)-1,3-propanediamine (L-2)] have been synthesized. The thiodiamines coordinate as a bidentate N-S ligand. The synthesized platinum (IV) and palladium (II) complexes of the thiodiamines were characterized by elemental analysis, IR, mass, electronic and III NMR spectroscopic studies. These complexes were also screened for cytotoxicity, in vitro antifungal and in vitro antibacterial activities. Thermodynamic parameters such as activation energy (E-a), apparent activation entropy (S-#) and enthalpy change (Delta H) for the dehydration and decomposition reactions of one complex has also been evaluated. (c) 2007 Elsevier Masson SAS. All rights reserved.