Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 42, Issue 10, Pages 1239-1246Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2007.03.017
Keywords
synthesis; spectral; cytototoxicity; antibacterial; antifungal and thermal
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Some new platinum (IV) and palladium (II) thiodiamine complexes of type [Pt(L)(2)Cl-2] and [Pd(L)Cl-2], [where, L = (cyclohexyl-N-thio)-1,2ethylenediamine (L-1) and (cyclohexyl-N-thio)-1,3-propanediamine (L-2)] have been synthesized. The thiodiamines coordinate as a bidentate N-S ligand. The synthesized platinum (IV) and palladium (II) complexes of the thiodiamines were characterized by elemental analysis, IR, mass, electronic and III NMR spectroscopic studies. These complexes were also screened for cytotoxicity, in vitro antifungal and in vitro antibacterial activities. Thermodynamic parameters such as activation energy (E-a), apparent activation entropy (S-#) and enthalpy change (Delta H) for the dehydration and decomposition reactions of one complex has also been evaluated. (c) 2007 Elsevier Masson SAS. All rights reserved.
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