Journal
PHYTOTHERAPY RESEARCH
Volume 21, Issue 10, Pages 970-974Publisher
WILEY
DOI: 10.1002/ptr.2198
Keywords
plant extracts; antiviral activity; MTT assay; viral cytopathic effect; HSV-1; rabies virus
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This paper describes the screening of different South American plant extracts and fractions. Aqueous and organic extracts were prepared and tested for antiherpetic (HSV-1, KOS and 29R strains) and antirabies (PV strain) activities. The evaluation of the potential antiviral activity of these extracts was performed by using an MTT assay for HSV-1, and by a viral cytopathic effect (CPE) inhibitory method for rabies virus (RV). The results were expressed as 50% cytotoxicity (CC50) for MTT assay and 50% effective (EC50) concentrations for CPE, and with them it was possible to calculate the selectivity indices (SI = CC50/EC50) of each tested material. From the 18 extracts/fractions tested, six extracts and four fractions showed antiviral action. Ilex paraguariensis, Lafoensia pacari, Passiflora edulis, Rubus imperialis and Slonea guianensis showed values of SI > 7 against HSV-1 KOS and 29-R strains and Alamanda schottii showed a SI of 5.6 against RV, PV strain. Copyright (c) 2007 John Wiley & Sons, Ltd.
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