Journal
TRENDS IN GENETICS
Volume 23, Issue 10, Pages 480-484Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.08.003
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Funding
- Medical Research Council [G0300415] Funding Source: researchfish
- MRC [G0300415] Funding Source: UKRI
- Medical Research Council [G0300415] Funding Source: Medline
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In diverse organisms, neighbouring genes in the genome tend to be positively coexpressed more than expected by chance. When the similarity of transcription regulation is controlled for, adjacent genes have much higher coexpression rates than unlinked genes, supporting a role for chromatin modelling. Consequently, many incidences of low-to-moderate level coexpression of linked genes might well be spurious rather than an indication of functional coordination. These results have implications for gene therapy and for understanding gene order evolution, suggesting that chromosomal proximity alone is adequate to achieve some level of coexpression.
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