Journal
NEUROCHEMICAL RESEARCH
Volume 32, Issue 10, Pages 1720-1725Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-007-9333-x
Keywords
Alzheimer's disease; AB peptides; resveratrol; tea catechins; transthyretin; polyphenols; neuroprotection; beta-amyloid; PKC
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Various studies reported on the neuroprotective effects of natural products, particularly polyphenols, widely present in food and beverages. For example, we have shown that resveratrol, a polyphenol contained present in red wine and other foods, activates the phosphorylation of protein kinase C (PKC), this effect being involved in its neuroprotective action against AB-induced toxicity. Moreover, tea-derived catechin gallate esters inhibit the formation AB oligomers/fibrils, suggesting that this action likely contributes to their neuroprotective effects. Interestingly, the effects of polyphenols may be attributable, at least in part, to the presence of specific binding sites. Autoradiographic studies revealed that these binding sites are particularly enriched in choroids plexus in the rat brain. Interestingly, the choroid plexus secretes transthyretin, a protein that has been shown to prevent A beta aggregation and that may be critical to the maintenance of normal learning capacities in aging. Taken together, these data suggest that polyphenols target multiple enzymes/proteins leading to their neuroprotective actions.
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