Journal
ANAESTHESIST
Volume 63, Issue 10, Pages 775-782Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00101-014-2369-9
Keywords
Bacterial infections; Intensive care medicine; Dosing; Minimum inhibitory concentration; Individualized medicine
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Antibiotic agents are crucial pillars in intensive care medicine and must be used rationally and sensibly. In the case of critically ill patients optimal dosing with respect to pharmacokinetic and pharmacodynamic principles (PK/PD) can be vital. Preclinical results demonstrated important differences between antibiotic classes and gave rise to differing clinical dosing strategies, e.g. high dose once daily regimens for aminoglycosides or extended/continuous infusion of betalactams. Critically ill patients with altered pharmacokinetic parameters and infections by pathogens with low susceptibility are most likely to benefit from PK/PD-guided therapy.
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