Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 11, Issue 5, Pages 537-542Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2007.08.011
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Funding
- NIGMS NIH HHS [R01 GM059159, GM59159] Funding Source: Medline
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Flexizymes are de novo ribozymes capable of charging a wide variety of non-natural amino acids on tRNAs. The flexizyme system enables reprogramming of the genetic code by reassigning the codons that are generally assigned to natural amino acids to non-natural residues, and thus mRNA-directed synthesis of non-natural polypeptides can be achieved. In this review, we comprehensively summarize the history of the flexizyme system and its subsequent development into a practical tool. Furthermore, applications to the synthesis of novel biopolymers via genetic code reprogramming and perspectives for future applications are described.
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