Journal
NEUROBIOLOGY OF DISEASE
Volume 28, Issue 1, Pages 3-15Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2007.06.015
Keywords
Alzheimer's disease; amyloid; forebrain; transgenics; acetylcholine; ChAT activity; AChE; stereology; interneurons; degeneration
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Funding
- NIA NIH HHS [R01 AG043375, R01 AG010668-14A1, R01 AG010668, P01 AG014449] Funding Source: Medline
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The impact of Delta beta deposition upon cholinergic intrinsic cortical and striatal, as well as basal forebrain long projection neuronal systems was qualitatively and quantitatively evaluated in young (2-6 months) and middle-aged (10-16 months) APPswe/PS1 Delta E9 transgenic (tg) mice. Cholinergic neuritic swellings occurred as early as 2-3 months of age in the cortex and hippocampus and 5-6 months in the striatum of tg mice. However, cholinergic neuron number or choline acetyltransferase (ChAT) optical density measurements remained unchanged in the forebrain structures with age in APPswe/PS1 Delta E9 tg mice. ChAT enzyme activity decreased significantly in the cortex and hippocampus of middle-aged tg mice. These results suggest that A 0 deposition has age-dependent effects on cortical and hippocampal ChAT fiber networks and enzyme activity, but does not impact the survival of cholinergic intrinsic or long projection forebrain neurons in APPswe/ PS1 Delta E9 tg mice. (C) 2007 Elsevier Inc. All rights reserved.
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