Journal
TETRAHEDRON LETTERS
Volume 48, Issue 40, Pages 7120-7124Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.07.214
Keywords
chemical biology; multi-component reaction; domino process; biasing element; spiro compound.
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A small library of peculiar biphenyl and terphenyl-containing spirocyclic triones has been synthesized in parallel by combining the organocatalytic three-component domino Knoevenagel/Diels-Alder sequence to Suzuki coupling. This methodology is fast. general and serves as a platform to gain access to novel chemical tools to probe protein-protein interactions. (c) 2067 Elsevier Ltd. All rights reserved.
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