Journal
CELL CALCIUM
Volume 42, Issue 4-5, Pages 373-378Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ceca.2007.05.012
Keywords
Ca2+ signalling; endoplasmic reticulum; Ca2+ release; Ca2+ tunnel; secretory cells; neurones
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One of the most crucial aspects of Ca2+ signalling is the ability to generate highly localised transient elevations of the cytosolic Ca2+ concentration at specific strategically important target sites. Inevitably this necessitates a relatively high Ca2+ buffering power of the cytoplasm, which in turn makes movement of Ca2+ from one part of a cell to another difficult. Nature has evolved an elegant solution to this problem by creating operational Ca2+ tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided. (c) 2007 Elsevier Ltd. All rights reserved.
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