Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 190, Issue 1-2, Pages 165-169Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.08.007
Keywords
interferon beta; Binding antibodies; Neutralizing antibodies
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Clinical studies demonstrate differences in interferon-beta (IFN beta) antibody detection frequencies among multiple sclerosis patients receiving different IFN beta products. We sought to determine if these differences are also found when IFN beta antibodies are measured in a reference laboratory, where factors normally controlled in clinical studies are unknown. Serum IFN beta binding antibodies (BAbs) were quantitated by ELISA; BAbs-positive samples were then tested in a bioassay for neutralizing antibodies (NAbs). Consistent with clinical studies, frequencies of BAbs-positive sera and NAbs-positive sera were lower in the Avonex (IFN beta-1a) treatment group than Rebif (IFN beta-1a) and Betaseron (IFN beta-1b) groups. We further identified a predictive relationship between positive BAbs levels and NAbs activity in patients treated with IFN beta-1a products, but not those treated with IFN beta-1b. (C) 2007 Elsevier B.V. All rights reserved.
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