Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 17, Issue 5, Pages 513-520Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2007.09.002
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Funding
- NIGMS NIH HHS [F32GM083352, F32 GM083352, R01 GM070589-01, R01 GM070589] Funding Source: Medline
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Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for enclogenous lectins. Galectins, a family of animal lectins with affinity for beta-galactosides, can form multivalent complexes with cell surface glycoconjugates and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival, Recent efforts involving genetic or biochemical manipulation of O-glycosylation and N-glycosylation pathways, as well as blockade of the synthesis of enclogenous galectins, have illuminated essential roles for galectin-glycoprotein lattices in the control of biological processes including receptor turnover and endocytosis, host-pathogen interactions, and immune cell activation and homeostasis.
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