Journal
NATURE IMMUNOLOGY
Volume 8, Issue 10, Pages 1060-1066Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1505
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Funding
- Wellcome Trust Funding Source: Medline
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Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 alpha-chain (CD8 alpha) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8(+) 'killer' T cells responded to influenza virus antigens presented by lymph node-resident CD8 alpha(+) DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.
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