Journal
BIOLOGICAL PSYCHIATRY
Volume 62, Issue 7, Pages 818-821Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.10.031
Keywords
antipsychotic treatment effects; attention; dopamine; first-episode schizophrenia; prefrontal cortex; working memory
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Funding
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NCRR NIH HHS [M01 RR00056] Funding Source: Medline
- NIMH NIH HHS [MH45156, MH01433, MH62134] Funding Source: Medline
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Background: This study sought to replicate previous findings of worsened performance on a translational spatial working memory task among antipsychotic-naive first-episode schizophrenia patients after antipsychotic treatment and to extend these findings by examining whether changes in the allocation of covert attention contribute to this effect. Methods: Fourteen antipsychotic-naive schizophrenia patients performed an oculomotor delayed response task before and 6 weeks after antipsychotic treatment (risperidone n = 11; olanzapine n = 3). Fifteen matched healthy individuals were studied in parallel. Results: Patients' pretreatment deficit inaccurately remembering spatial locations was exacerbated by antipsychotic treatment, consistent with previous findings; however, this occurred only when covert attention was directed away from remembered locations during delay periods. Conclusions: Disruption in the allocation of covert attention might contribute to patients' decline in spatial working memory after antipsychotic treatment. Alterations in prefrontal dopaminergic systems or reduced thalamocortical drive might account for this apparent adverse cognitive effect of antipsychotic treatment.
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