Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 455, Issue 1, Pages 157-168Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-007-0275-6
Keywords
TRP; PIP2; PtdIns(4,5)P-2; TRPV; TRPM; TRPC; TRPA
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Funding
- NINDS NIH HHS [R01 NS055159] Funding Source: Medline
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This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.
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