Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 14-15, Pages 2213-2233Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700252
Keywords
ball mill; carbon-carbon bond formation; organocatalysis; solid-solid reactions; solvent-free
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Ball milling has been applied in numerous solvent-free carbon-carbon bond formations. In many cases, these transformations proved superior to the analogous reactions performed in solution. The reaction scope involves purely organic addition and coupling reactions, transformations involving metals (in stoichiometric and catalytic amounts) as well as asymmetric organocatalyses.
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