Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 14, Issue 10, Pages 1372-1376Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00202-07
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Funding
- NIAID NIH HHS [AI-51519, P30 AI051519, R01 AI056070, AI52733, AI056070-01A2, R01 AI052733] Funding Source: Medline
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Glucosylceramides (GIcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
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