Journal
JOURNAL OF INTERNAL MEDICINE
Volume 262, Issue 4, Pages 431-438Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2796.2007.01854.x
Keywords
adipose tissue; cytokine; inflammation; lipolysis; macrophage
Categories
Ask authors/readers for more resources
From its initial implication in the development of cachexia in the early 1980s, it is now almost 15 years ago that tumour necrosis factor-alpha (TNF-alpha) was first shown to be involved in the development of insulin resistance in obesity. Since the original findings in mice, a wealth of data has been obtained in a variety of settings and species. This intensive research has demonstrated both similarities and differences between rodents and humans regarding the molecular mechanisms and metabolic consequences of TNF-alpha overexpression. This review will focus on the role of TNF-alpha in human white adipose tissue with particular emphasis on its regulation of lipolysis - an important pathway in adipocytes which is linked to insulin-resistant phenotypes in obesity and the metabolic syndrome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available