Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 18, Issue 5, Pages 583-590Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.07.010
Keywords
cholesterol; liquid ordered; lipid probes; IgE receptors; mast cells
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Funding
- NIAID NIH HHS [R01 AI022449, R01 AI022449-20] Funding Source: Medline
- PHS HHS [A122449] Funding Source: Medline
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Novel biophysical approaches combined with modeling and new biochemical data have helped to recharge the lipid raft field and have contributed to the generation of a refined model of plasma membrane organization. In this review, we summarize new information in the context of previous literature to provide new insights into the spatial organization and dynamics of lipids and proteins in the plasma membrane of live cells. Recent findings of large-scale separation of liquid-ordered and liquid-disordered phases in plasma membrane vesicles demonstrate this capacity within the complex milieu of plasma membrane proteins and lipids. Roles for membrane heterogeneity and reorganization in immune cell activation are discussed in light of this new information. (C) 2007 Elsevier Ltd. All rights reserved.
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