Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 46, Issue 7, Pages 406-417Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-007-0680-9
Keywords
cardiovascular disease; fructose; metabolic syndrome; obesity; uric acid
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Funding
- NHLBI NIH HHS [HL-68607] Funding Source: Medline
- NIDDK NIH HHS [DK-52121] Funding Source: Medline
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The glycemic index (G.I.) is a means for categorizing carbohydrates based on their ability to raise blood glucose, subsequently this index has been popularized as a way for selecting foods to reduce the risk for obesity, diabetes, and cardiovascular disease. We suggest that the G.I. is better aimed at identifying foods that stimulate insulin secretion rather than foods that stimulate insulin resistance. In this regard, fructose has a low G.I. but may be causally linked with the obesity and cardiovascular disease epidemic. The reported association of high G.I. with cardiovascular dis- ease may be due to the association of sugar intake which contains fructose, but which has a high G.I. due to its glucose content. We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population.
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