Journal
STROKE
Volume 38, Issue 10, Pages 2851-2854Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.107.487280
Keywords
diffusion-weighted magnetic resonance imaging; neuroprotection; oxygen therapy; proton magnetic resonance spectroscopic imaging; stroke
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Funding
- NINDS NIH HHS [R01 NS38477, R01 NS051412, P50 NS051343, AND R01 NS050041] Funding Source: Medline
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Background and Purpose - Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke. Methods - We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy. Results - Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients. Conclusion - These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.
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