Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 4, Issue 7, Pages 460-463Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018007781788516
Keywords
multinuclear polyamine complexes; Pt(II); Pd(II); spermine; cytotoxic activity; anticancer potential
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The cytotoxic activity of (PdCl2)(2)(spermine) against a human cancer cell line (HSC-3) was evaluated. The results show an activity higher than that of the analogous Pt(II) chelate and, for 24 h incubations, identical to that of cisplatin. They also suggest a faster intracellular uptake and DNA binding relative to cisplatin.
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