Journal
MEDICAL CARE
Volume 45, Issue 10, Pages S13-S15Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MLR.0b013e318041f752
Keywords
comparative effectiveness; bias; confounding
Categories
Funding
- PHS HHS [HHSA290200500361] Funding Source: Medline
Ask authors/readers for more resources
Studies of patient safety and comparative effectiveness entail unique methodologic challenges. These studies may be susceptible to systematic error, including selection bias, exposure misclassification, and outcome misclassification. They may also be vulnerable to random error, or confounding by a variable such as another drug, a disease, or the drug indication itself. Finally, special logistical issues can arise, including data access problems, difficulties in conveying the need for studies of certain interventions, and obstacles to gaining institutional review board approval. This article provides a conceptual overview of these methodologic issues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available