Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 10, Pages 1593-1600Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0702436
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Three new analogues of dolastatin 13, termed lyngbyastatins 5-7 (1-3), were isolated from two different collections of marine cyanobacteria, Lyngbya spp., from South Florida. Their planar structures were deduced by a combination of NMR techniques, and the absolute configurations were established by modified Martey's analysis of the acid hydrolyzates. The related cyclodepsipeptide somamide B (4), previously reported from a Fijian cyanobacterium, has also been found in one of the extracts, and its absolute stereochemistry was unambiguously assigned for the first time. Compounds 1-4 were found to selectively inhibit elastase over several other serine proteases, with IC50 values for porcine pancreatic elastase ranging from 3 to 10 nM.
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