Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 82, Issue 4, Pages 435-440Publisher
WILEY
DOI: 10.1038/sj.clpt.6100331
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Funding
- NHLBI NIH HHS [1-U01 HL69012-01, U01 HL 69009-02] Funding Source: Medline
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The goal of this experiment was to identify the presence of genetic variants in the adenosine receptor genes and assess their relationship to infarct size in a population of patients with ischemic cardiomyopathy. Adenosine receptors play an important role in protecting the heart during ischemia and in mediating the effects of ischemic preconditioning. We sequenced DNA samples from 273 individuals with ischemic cardiomyopathy and from 203 normal controls to identify the presence of genetic variants in the adenosine receptor genes. Subsequently, we analyzed the relationship between the identified genetic variants and infarct size, left ventricular size, and left ventricular function. Three variants in the 30-untranslated region of the A1-adenosine gene ( nt 1689 C/A, nt 2206 Tdel, nt 2683del36) and an informative polymorphism in the coding region of the A3-adenosine gene ( nt 1509 A/C I248L) were associated with changes in infarct size. These results suggest that genetic variants in the adenosine receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.
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