Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 37, Issue 10, Pages 2707-2714Publisher
WILEY
DOI: 10.1002/eji.200737173
Keywords
conventional dendritic cell; Ly49Q; plasmacytoid; dendritic cell; type I; interferon
Categories
Ask authors/readers for more resources
Ly49Q is expressed on peripheral mouse plasmacytoid dendritic cells (pDC). Immature Ly49Q-negative pDC precursors acquire Ly49Q in the bone marrow and then migrate into the periphery. While searching for molecules that regulate pDC maturation, we found that type I interferon (IFN) inhibited Ly49Q acquisition in vitro. Infections that induce type I IFN production by cells other than pDC (a condition mimicked by poly(I:C) injection in vivo) increase the prevalence of Ly49Q(-) pDC in the bone marrow and peripheral lymphoid organs in wild-type but not IFN-alpha/beta receptor knockout BALB/c mice. Moreover, in vivo exposure to type I IFN causes some Ly49Q(-), but not Ly49Q(+), pDC to convert to conventional DC, defined as B220(-) CD11c(+) CD11b(+) cells. These data. suggest that type I IFN regulates pDC development and affects their distribution in the body.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available