Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 7, Issue 10, Pages 984-990Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955707782110123
Keywords
glioma; glioblastoma multiforme; sphingolipids; sphingosine-1-phosphate; ceramide
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Funding
- NINDS NIH HHS [R01 NS41517] Funding Source: Medline
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Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and SIP leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways.
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