Journal
IMMUNITY
Volume 27, Issue 4, Pages 660-669Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2007.08.013
Keywords
-
Categories
Ask authors/readers for more resources
How the development of antibacterial T helper 17 (Thl 7) cells is selectively promoted by antigen-presenting dendritic cells (DCs) is unclear. We showed that bacteria, but not viruses, primed human DCs to promote IL-17 production in memory Th cells through the nucleoticle oligomerization domain 2 (NOD2)-ligand muramyldipeptide (MDP), a derivative of bacterial peptidoglycan. MDP enhanced obligate bacterial Toll-like receptor (TLR) agonist induction of IL-23 and IL-1, which promoted IL-1 7 expression in T cells. The role of NOD2 in this IL-23-IL-1 -IL17 axis could be confirmed in NOD2-deficient DCs, such as DCs from selected Crohn's disease patients. Thus, antibacterial Thl 7-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available