Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 34, Issue 7, Pages 849-853Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nucmedbio.2007.05.003
Keywords
sentinel lymph node biopsy; radiopharmaceutical; [Tc-99]DTPA; mannosyl-dextran-lymphoseek; molecular imaging; breast cancer
Funding
- NCI NIH HHS [R21 CA097643, P50 CA128346, R21-CA09764] Funding Source: Medline
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Lyrnphoseek is a molecular imaging agent specifically designed for sentinel lymph node (SLN) mapping. We conducted a Phase I trial which measured the injection site clearance and SLN accumulation after a single intra dermal injection of Lymphoseek or [99(m)Tc]sulfur colloid protocol. Ten patients with breast cancer participated in this study. Five patients received an intradermal administration of 1.0 nmol of 99(m)Tc-labeled Lymphoseek and five patients received an intradermal administration of filtered [99(m)Tc]sulfur colloid (fTcSC). Lymphoseek exhibited a significantly (P< 001) faster injection site clearance than freSC. The mean Lymphoseek clearance half-time was 2.61 +/- 0.72 h compared to 24.1 +/- 17.7 h for fFcSC. The mean SLN uptake of Lymphoseek (1.1 +/- 5%) and fTcSC (2.5 +/- 4.9%) was statistically equivalent (P=.28). When an intra dermal injection was employed, Lymphoseek demonstrated faster injection site clearance than fFcSC. (C) 2007 Elsevier Inc. All rights reserved.
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