Journal
JOURNAL OF IMMUNOLOGY
Volume 179, Issue 7, Pages 4520-4528Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.179.7.4520
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI 42135, AI 39031] Funding Source: Medline
Ask authors/readers for more resources
Regulation of CD8 T cell expansion and contraction is essential for successful immune defense against intracellular pathogens. IIL-10 is a regulatory cytokine that can restrict T cell responses by inhibiting APC functions. IL-10, however, can also have direct effects on T cells. Although blockade or genetic deletion of IIL-10 enhances T cell-mediated resistance to infections, the extent to which IL-10 limits in vivo APC function or T cell activation/proliferation remains unknown. Herein, we demonstrate that primary and memory CD8 T cell responses following Listeria monocytogenes infection are enhanced by the absence of IL-10. Surface expression of the IL-10R is transiently up-regulated on CD8 T cells following activation, suggesting that activated T cells can respond to EL-10 directly. Consistent with this notion, CD8 T cells lacking IL-10R2 underwent greater expansion than wild-type T cells upon L monocytogenes infection. The absence of IL-10R2 on APCs, in contrast, did not enhance T cell responses following infection. Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available