Journal
CELL CALCIUM
Volume 42, Issue 4-5, Pages 439-446Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2007.05.014
Keywords
CRAC; T-lymphocytes; mast cells; ORAI; STIM
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Recently ORAI and STIM proteins were identified as components of the CRAC channel and the endoplasmic reticulum Ca2+ sensor, respectively. The ORAI proteins share a predicted structure that includes four transmembrane domains with intracellular N- and C-termini. They share structural similarity with proteins of the tetraspanin superfamily which includes the gamma subunits of voltage-activated Ca2+ channels (CaV gamma), the transmembrane AMPA regulatory proteins (TARPs), the claudins and the tumor-associated membrane proteins (TMPs). The mouse genome contains four genes which encode the ORAI1, ORAI2 and ORAI3 proteins and two genes which encode the type I single-pass transmembrane STIM1 and STIM2 proteins. ORAI2 transcripts are present in primary cortical neurons and ORAI1, 2, 3 and STIM1, 2 expression is readily detectable in CD3+/CD4+-, CD3+/CD8+-, and CD19+-lymphocytes as well as in mast cells from mouse. (c) 2007 Elsevier Ltd. All rights reserved.
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