Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 18, Issue 5-6, Pages 545-551Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2007.06.023
Keywords
type I interferon; RIG-I; RNA helicase; innate immunity
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Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate antiviral responses, including the activation of type I interferon (IFN) and proinflammatory cytokines. Recent advances in cytoplasmic virus sensors highlight their essential role in the induction of innate immunity. Moreover, it is intriguing to understand how they can discriminate innate RNA from viral foreign RNA. In this mini-review, we focus on these cytoplasmic virus sensors, termed retinoic acid inducible gene-I (RIG-I)-like receptors (RLRs), and discuss their function in the innate immune system. (c) 2007 Elsevier Ltd. All rights reserved.
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