Journal
PLANTA MEDICA
Volume 73, Issue 12, Pages 1298-1303Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-981618
Keywords
Melia toosendan; meliaceae; limonoids; antibacterial; oral pathogen
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In this study five new limonoids, toosenclone [24,25,26,27-tetranor-6 alpha-acetoxy-21,22-epoxy-7 alpha-tigloyl-1 alpha 3 alpha,28-trihydroxya-potirucalla-(apoeupha)-14,20,22-trien-12-one, 1] and 12-ethoxynimbolinins A - D (2 - 5), together with five known limonoids, 1-acetyltrichilinin (6), 1-cinnamoyltrichilinin (7), trichilinin B (8), 1,7-di-O-acetyl-14,15-deoxyhavanensin (9) and 12-O-methylnimbolinin B (10),were isolated from the fruits of Melia toosendan. Their structures and relative configurations were established based on spectroscopic analysis. Compound 4 exhibited significant antibacterial activity against the oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.6 mu g/mL. Compounds 7 and 8 were also active against P. gingivalis ATCC 33277, with MIC values of 31.3 and 31.5 mu g/mL respectively.
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