Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 7, Issue 10, Pages 1575-1582Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.7.10.1575
Keywords
innate autoimmunity; ischemia-reperfusion injury; natural IgM
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Recent studies showed that innate autoimmunity is an early mechanism for ischemia-reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. in contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.
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