Journal
BLOOD COAGULATION & FIBRINOLYSIS
Volume 18, Issue 7, Pages 637-646Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0b013e3282a167bb
Keywords
blood coagulation; contact activation; thrombin; thrombosis; tissue factor
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A mathematical model has been developed to simulate the generation of thrombin through intrinsic and extrinsic pathways. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the kinetics due to a decrease or deficiency in the concentrations of coagulation proteins or their activities was studied. The model gives reasonable predictions without the adjustment of any parameter values. The calculated clotting time was approximately 44s for the intrinsic pathway and approximately 8.6 s for the extrinsic pathway using normal protein concentrations in plasma. Various prolonged clotting times were observed in different factor-deficient disorders using this model. Blood Coagul Fibrinolysis 18:637-646 (c) 2007 Lippincott Williams & Wilkins.
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