An efficient and practical process for Pd/Cu cocatalyzed homocoupling reaction of terminal Alkynes using sodium percarbonate as a dual reagent in aqueous media

A new process for the Pd/Cu co-catalyzed homocoupling reaction of terminal alkynes was developed. The reaction was carried out in aqueous media with sodium percarbonate as both a clean oxidant and a base. Meanwhile, a palladium complex immobilized on a synthetic PS-PEG(400)-PPh2 resin was used as the catalyst, which may be recovered by simple filtration and reused for several times with high activity.