Journal
FEBS LETTERS
Volume 581, Issue 24, Pages 4754-4760Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.08.075
Keywords
cortical neuron; neurite outgrowth; PCP gene; postmitotic neuron; prickle
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The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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