Journal
CELL
Volume 131, Issue 1, Pages 146-159Publisher
CELL PRESS
DOI: 10.1016/j.cell.2007.07.021
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Funding
- NCI NIH HHS [R01 CA085842, CA85842] Funding Source: Medline
- NIAID NIH HHS [AI054636, AI059294, R01 AI059294, AI064345] Funding Source: Medline
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MiR-150 is a microRNA ( miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Our results identify a key transcription factor as a critical target of a stage-specifically expressed miRNA in lymphocytes and suggest that this and perhaps other miRNAs have evolved to control the expression of just a few critical target proteins in particular cellular contexts.
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