Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1167, Issue 1, Pages 116-119Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2007.08.034
Keywords
room temperature ionic liquids; residual solvents; static headspace gas chromatography; pharmaceutical analysis
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Using new solvent room temperature ionic liquid (IL) matrix media, testing of residual solvents in pharmaceutical preparations with static headspace gas chromatographic (SH-GC), is described. The purpose of this work was to demonstrate the feasibility of IL as diluent, six solvents utilized in synthesis of Adefovir Dipivoxil: acetonitrile, dichloromethane, N-methyl-2-pyrrolidone (NMP), toluene, dimethylformamide (DMF), n-butyl ether were dissolved in IL: 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4). The method of external standard was used for quantitative analysis. Its performance was evaluated and validated: all the RSD were lower than 10%, the limits of detection were all of the ppm level and the method was both accurate and linear. And better sensitivities for the six solvents were gained with [bmim]BF4 as diluent comparing with DMSO. (C) 2007 Elsevier B.V. All rights reserved.
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