Journal
SCIENCE
Volume 318, Issue 5847, Pages 116-120Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1146291
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI56172, P01 AI056172-05, P01 AI056172, R01 AI041576-06, AI41576, R01 AI041576] Funding Source: Medline
- PHS HHS [DRG-1886-05] Funding Source: Medline
Ask authors/readers for more resources
Mounting a protective immune response is critically dependent on the orchestrated movement of cells within lymphoid organs. We report here the visualization, using major histocompatability complex class I tetramers, of the CD8-positive (CD8) T cell response in the spleens of mice to Listeria monocytogenes infection. A multistage pathway was revealed that included initial activation at the borders of the B and T cell zones followed by cluster formation with antigen-presenting cells leading to CD8 T cell exit to the red pulp via bridging channels. Strikingly, many memory CD8 T cells localized to the B cell zones and, when challenged, underwent rapid migration to the T cell zones where proliferation occurred, followed by egress via bridging channels in parallel with the primary response. Thus, the ability to track endogenous immune responses has uncovered both distinct and overlapping mechanisms and anatomical locations driving primary and secondary immune responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available