Journal
SCIENCE
Volume 318, Issue 5847, Pages 109-112Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1146565
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- Natural Environment Research Council [NE/C507629/1] Funding Source: researchfish
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The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range of loci in the genome. At some target loci, FCA and FPA promote asymmetric DNA methylation, whereas at others they function in parallel to DNA methylation. Female gametophytic development and early embryonic development are particularly susceptible to malfunctions in FCA and FPA. We propose that FCA and FPA regulate chromatin silencing of single and low-copy genes and interact in a locus-dependent manner with the canonical small interfering RNA-directed DNA methylation pathway to regulate common targets.
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