Journal
NEUROREPORT
Volume 18, Issue 15, Pages 1567-1570Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282ef7082
Keywords
bipolar disorder; brain-derived neurotrophic factor; brain-derived neurotrophic factor polymorphism; dorsolateral prefrontal cortex; magnetic resonance spectroscopy
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Funding
- NCRR NIH HHS [RR 20571] Funding Source: Medline
- NIMH NIH HHS [MH 068662, MH 68766] Funding Source: Medline
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Brain-derived neurotrophic factor va166met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor va166met polymorphism using 'H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr + Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex.
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