Journal
TETRAHEDRON LETTERS
Volume 48, Issue 41, Pages 7263-7265Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.08.049
Keywords
imidazo[1,2-a]pyridines; imidazo[2,1-b][1,3]thiazoles; isocyanides; three-component reactions; catalyst-free synthesis in water
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A catalyst-free and convenient protocol is described for the preparation of 3-aminoimidazo[1,2-a]pyridines and 5-aminoimidazo[2,1-b][1,3]thiazoles via three-component reactions between 2-aminopyridines or 2-aminothiazoles, aldehydes, and isocyanides in water in good to excellent yields. (c) 2007 Elsevier Ltd. All rights reserved.
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